Saracens welcome back some of their England internationals from Six Nations duty. Ben Earl, Theo Dan, Jamie George and Elliot Daly are in the matchday squad but Maro Itoje is not involved. Owen Farrell starts at fly-half and captains the side on his 250th appearance.
Saracens: 1 Mako Vunipola, 2 Theo Dan, 3 Christian Judge, 4 Theo McFarland, 5 Hugh Tizard, 6 Juan Martin Gonzalez, 7 Ben Earl, 8 Billy Vunipola; 9 Ivan van Zyl, 10 Owen Farrell (c), 11 Alex Lewington, 12 Nick Tompkins, 13 Lucio Cinti, 14 Rotimi Segun, 15 Elliot Daly
Replacements: 16 Jamie George, 17 Eroni Mawi, 18 Marco Riccioni, 19 Nick Isiekwe, 20 Tom Willis, 21 Andy Christie, 22 Gareth Simpson, 23 Alex Goode
Harlequins include six returning internationals from the Six Nations. Joe Marler, Alex Dombrandt, Danny Care and Marcus Smith return from England duty whilst Italy’s Louis Lynagh and Wales’ Dillon Lewis are also included in the matchday 23. Andre Esterhuizen, who will join the Sharks in South Africa in the summer, starts at inside centre. Luke Northmore could make his first appearance since October from the bench.
Harlequins: 1. Joe Marler 2. Jack Walker 3. Will Collier 4. Joe Launchbury 5. George Hammond 6. Stephan Lewies (Captain) 7. Will Evans 8. Alex Dombrandt 9. Danny Care 10. Marcus Smith 11. Cadan Murley 12. Andre Esterhuizen 13. Oscar Beard 14. Louis Lynagh 15. Tyrone Green
Replacements: 16. Sam Riley 17. Fin Baxter 18. Dillon Lewis 19. Irne Herbst 20. Will Trenholm 21. Max Green 22. Luke Northmore 23. Nick David